7-OH, Kratom Clinical Guidance
The Minnesota Medical Association (MMA) and the Minnesota Society of Addiction Medicine (MNSAM) developed this clinical resource in partnership to support Minnesota clinicians caring for patients who use concentrated 7-hydroxymitragynine (7-OH) and related kratom-derived products.
These products can produce opioid-like effects and may be associated with dependence, withdrawal, and other serious adverse effects. At the same time, the evidence base for treatment remains limited, product labeling and potency can be unreliable, and clinicians may encounter significant variation in patient presentation.
The guidance package was developed to provide a practical, Minnesota-specific framework for assessment and buprenorphine initiation across inpatient, outpatient, and at-home settings. It is intended to support clinical decision-making, not replace clinical judgment, local policy, toxicology consultation, or emergency care. Because treatment evidence for 7-OH remains limited, this resource incorporates established opioid use disorder practice and the experience of Minnesota clinicians caring for this emerging patient population.
Tools & Resources
MN Kratom, 7-OH and Mitragynine Semisynthetic Derivates Treatment Management October 2026
Disclaimer
This guidance is intended solely for educational and information purposes to assist qualified healthcare professionals in the administration of buprenorphine. It does not constitute formal medical advice, establish a binding standard of care, replace the independent professional clinical judgment of the treating healthcare professional, or establish a doctor-patient relationship. Healthcare professionals must tailor treatment plans to the individual needs, medical history, and specific circumstances of each patient. Medical knowledge is constantly evolving, and it is the responsibility of the healthcare professional to stay informed of the latest clinical guidelines, safety alerts, and prescribing information issued by regulatory bodies and manufacturers. Healthcare professionals are also responsible for ensuring that their practice complies with local, state, and federal laws and regulations. Patients with health care related questions or concerns are advised to contact a physician or other qualified health care professional.
The Minnesota Medical Association shall not be liable for direct, indirect, special, incidental or consequential damages related to the user’s decision to use this information contained herein.